亚洲中字幕最新2021芒果

亚洲中字幕最新2021芒果:导师简介―刘李

亚洲中字幕最新2021芒果:

发布者:刘芳 发布时间:2016-11-09 浏览次数:

刘李,男,1981年9月生,中共党员,博士,中国药科大学副教授。主要研究方向:药物代谢动力学。
1、个人概况:
 中国药科大学,副教授,硕士生导师。专业方向为药物代谢动力学。
2、承担课题:
 主持2011年国家自然科学基金青年项目1项(基于胰高血糖素样肽-1释放调控诠释人参二醇型皂苷抗糖尿病作用及其机制,81102503);参与三项科技部“重大新药创制” (2011ZX09102-009、2011ZX091022-022、2009ZX09501-003)的研究。
3、近年来发表有代表性学术论文
1. Guo H, Liu C, Li J, Zhang M, Hu M, Xu P, Liu L*, Liu X*. A mechanistic physiologically based pharmacokinetic-enzyme turnover model involving both intestine and liver to predict CYP3A induction-mediated drug-drug interactions. J Pharm Sci. 2013; 102(8): 2819-36. [Co-corresponding author]
2. Liu C, Zhang M, Hu MY, Guo HF, Li J, Yu YL, Jin S, Wang XT, Liu L*, Liu XD*. Increased glucagon-like peptide-1 secretion may be involved in antidiabetic effects of ginsenosides. J Endocrinol. 2013; 217(2): 185-96. [Co-corresponding author]
3. Yu Y, Wang X, Liu C, Yao D, Hu M, Li J, Hu N, Liu L*, Liu X*. Combined contributions of over-secreted glucagon-like peptide 1 and suppressed insulin secretion to hyperglycemia induced by gatifloxacin in rats. Toxicol Appl Pharmacol. 2013; 266(3): 375-84.  [Co-corresponding author]
4. Duan R, Hu N, Liu HY, Li J, Guo HF, Liu C, Liu L*, Liu XD*. Biphasic regulation of P-glycoprotein function and expression by exogenous nitric oxide in Caco-2 cells. Acta Pharmacol Sin. 2012; 33(6): 767-74. [Co-corresponding author]
5. Liu L, Yu YL, Liu C, Wang XT, Liu XD, Xie L. Insulin deficiency induces abnormal increase in intestinal disaccharidase activities and expression under diabetic states, evidences from in vivo and in vitro study. Biochem Pharmacol. 2011; 82(12): 1963-70.
6. Liu L, Pan X, Liu HY, Liu XD, Yang HW, Xie L, Cheng JL, Fan HW, Xiao DW. Modulation of pharmacokinetics of theophylline by antofloxacin, a novel 8-amino-fluoroquinolone, in humans. Acta Pharmacol Sin. 2011; 32(10): 1285-93.
7. Liu L, Yu YL, Yang JS, Li Y, Liu YW, Liang Y, Liu XD, Xie L, Wang GJ.  Berberine suppresses intestinal disaccharidases with beneficial metabolic effects in diabetic states, evidences from in vivo and in vitro study. Naunyn Schmiedebergs Arch Pharmacol. 2010; 381(4): 371-81.
8. Liu L, Deng YX, Liang Y, Pang XY, Liu XD, Liu YW, Yang JS, Xie L, Wang GJ. Increased oral AUC of baicalin in streptozotocin-induced diabetic rats due to the increased activity of intestinal β-glucuronidase. Planta Med. 2010; 76(1):70-5.
9. Liu L, Deng Y, Yu S, Lu S, Xie L, Liu X. Berberine attenuates intestinal disaccharidases in streptozotocin-induced diabetic rats. Pharmazie. 2008; 63(5): 384-8.
10. Yao D, Liu L, Jin S, Li J, Liu XD. Overexpression of multidrug resistance-associated protein 2 in the brain of pentylenetetrazole-kindled rats. Neuroscience. 2012; 227: 283-92. [Co-first author]
11. Liu H, Liu L, Li J, Mei D, Duan R, Hu N, Guo H, Zhong Z, Liu X. Combined Contributions of Impaired Hepatic CYP2C11 and Intestinal Bcrp Activities and Expressions to Increased Exposure of Oral Glibenclamide in Streptozotocin-induced Diabetic Rats. Drug Metab Dispos. 2012; 40(6): 1104-12. [Co-first author]
12. Liu L, Ju HL, Zhang J, Liang Y, Liu XD, Xie L, Wang GJ. Development and validation of an LC-MS/MS method for determination of vorinostat in beagle dog plasma and its application to a pharmacokinetic study. Asian J Pharmacodyn Pharmacokinet. 2010; 10(3): 209-219.
4、指导研究生情况
2010年首次指导硕士生;现在指导硕士生5名;已毕业获学位硕士生2名。
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